Endocrine Abstracts

Background: In contrast to patients of European origin, primary adrenal insufficiency (PAI) in Indians is more common in males and often results from infectious etiologies (tuberculosis, Histoplasmosis). Most patients are treated with prednisolone, rather than hydrocortisone (HCT). A poor quality of life (QOL) has been reported in European patients with AD, but not in other populations. A few studies have also reported a high frequency of hypogonadism in PAI.<p class="abst...

Cushing’s disease (CD) results in chronic exposure to increased levels of cortisol leading to alterations in white matter microarchitecture and adverse effects on cognitive functioning. Diffusion tensor imaging (DTI) is a novel technique used to evaluate the integrity of white matter (WM) architecture. There is little information on DTI changes in CD. We studied WM changes in CD using diffusion tensor imaging and compared with healthy controls. 16 patients with active CD ...

Background: Autoimmune destruction is the most common aetiology of primary adrenal insufficiency (PAI) in Europe and north America. In contrast, tuberculosis is a common cause of PAI in developing countries. More recently, adrenal histoplasmosis (AH) is being increasingly reported from IndiaAims: To study the aetiology, clinical presentation and mortality in adults with PAI who were diagnosed between 2006-2019 and to determine the changes in aetiology si...

Introduction: Whether patients with non-surgical hypoparathyroidism have skeletal muscle dysfunction is not studied. It is also not known if skeletal muscle dysfunction involves respiratory muscles and results in a restrictive lung disease (RLD).Aim: To assess skeletal muscle and pulmonary function in patients with non-surgical hypoparathyroidism, who were asymptomatic for overt muscle and lung diseases.Methods: Thirty patients wit...

Introduction: Autoimmune polyendocrine syndrome 1 (APS1) is an uncommon, serious autosomal recessive disorder, due to AIRE gene mutations which result in impaired central tolerance. India has a complex genetic structure and also communities with high prevalence of consanguinity, which may result in varied clinical manifestations and genetic mutations.Aims: To study clinical features, interferon-α antibodies (IFNA), AIRE mutations, ...